Polymorphisms in the multidrug resistance gene MDR1 (ABCB1) predict for molecular resistance in patients with newly diagnosed chronic myeloid leukemia receiving high-dose imatinib

Abstract excerpt

To the editor: Recently, Dulucq and coworkers reported that multidrug resistance gene ( MDR1 ) polymorphisms were associated with major molecular responses (MMRs) to standard-dose imatinib in chronic myeloid leukemia (CML).[1][1] Significantly more patients homozygous for allele 1236T achieved a

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