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Article

Molecular study of ABCB1 gene and its correlation with imatinib response in chronic myeloid leukemia.

Cancer chemotherapy and pharmacology - 1 Oct 2017

Ben Hassine Islem, Gharbi Hanene, Soltani Ismail, Ben Hadj Othman Hind, Farrah Ahlem, Amouri Hassiba, Teber Mouheb, Ghedira Hela, Ben Youssef Yosra, Safra Ines, Abbes Salem, Menif Samia

Abstract excerpt

PURPOSE: The introduction and success of imatinib mesylate have become a paradigm shift in chronic myeloid leukemia (CML) treatment. However, despite its high efficiency, resistance to imatinib has emerged as a significant problem, which may in part be caused by pharmacogenetic variability. Three single-nucleotide polymorphisms (C1236T, G2677T/A, C3435T) and/or mRNA expression changes of ABCB1 gene were...

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Share to Antineoplastic Agents
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Gene Expression Regulation, Neoplastic

Share to Imatinib Mesylate

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Pharmacogenetics

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Source

Identifiers

PMID: 28836054
DOI: 10.1007/s00280-017-3424-4

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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