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Article

Association between C1236T Genetic Variant of ABCB1 Gene and Molecular Response to Imatinib in Indonesian Chronic Myeloid Patients.

Asian Pacific journal of cancer prevention : APJCP - 1 Nov 2019

Rinaldi Ikhwan, Nova Riki, Widyastuti Reni, Priambodo Rizky, Instiaty Instiaty, Louisa Melva

Abstract excerpt

OBJECTIVE: Imatinib is the first-line drug used for the treatment of chronic myeloid leukemia (CML) patients due to high molecular response and overall survival rate. However, some patients develop resistance to imatinib even after attaining a response. Mutation in ABCB1 efflux transporters is one of the known mechanisms of resistance to imatinib in chronic myeloid leukemia patients. This study was aimed to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31759356
DOI: 10.31557/APJCP.2019.20.11.3331
PMCID: PMC7063013

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