Article
Surfactant protein B gene polymorphism in preterm babies with respiratory distress syndrome.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Jan 2011
Lyra P P R, Diniz E M A, Abe-Sandes K, Angelo A L D, Machado T M B, Cardeal M
Abstract excerpt
The etiology of respiratory distress syndrome (RDS) is multifactorial and multigenic. Studies have suggested that polymorphisms and mutations in the surfactant protein B (SP-B) gene are associated with the pathogenesis of RDS. The objectives of this study were to determine and compare the frequencies of SP-B gene polymorphisms in preterm babies with and without RDS. We studied 151 neonates: 79 preterm babies...
Topics
- Case-Control Studies
- Female
- Genetic Markers
- Genetic Predisposition to Disease
- Genotype
- Humans
- Infant, Newborn
- Infant, Premature
- Male
- Polymerase Chain Reaction
- Polymorphism, Single Nucleotide
- Pulmonary Surfactant-Associated Protein B
- Respiratory Distress Syndrome, Newborn