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Article

Safety, tolerability, and pharmacokinetics of etamicastat, a novel dopamine-β-hydroxylase inhibitor, in a rising multiple-dose study in young healthy subjects.

Drugs in R&D - 1 Jan 2010

Nunes Teresa, Rocha José F, Vaz-da-Silva Manuel, Igreja Bruno, Wright Lyndon C, Falcão Amílcar, Almeida Luis, Soares-da-Silva Patricio

Abstract excerpt

BACKGROUND: Activation of the sympathetic nervous system is an important feature in hypertension and congestive heart failure. A strategy for directly modulating sympathetic nerve function is to reduce the biosynthesis of norepinephrine (noradrenaline) via inhibition of dopamine-β-hydroxylase (DβH). OBJECTIVE: To assess the safety, tolerability, and pharmacokinetics of etamicastat (BIA 5-453), a new DβH...

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Identifiers

PMID: 21171669
DOI: 10.2165/11586310-000000000-00000
PMCID: PMC3585840

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NAT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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