Article
Effect of glucose administration on hamster liver S9-mediated mutagenesis, metabolism and DNA-binding of benzo[a]pyrene and aflatoxin B1.
Cancer letters - 16 Jul 1990
Rubano D C, Teel R W, Strother A
Abstract excerpt
Hamster liver S9 prepared from control animals and animals given 30% glucose in drinking water 48 h before killing was used in studies of benzo[a]pyrene (BaP) and aflatoxin (AFB1)-induced mutagenesis, metabolism of BaP and AFB1, and metabolite binding to calf thymus DNA. BAP-induced mutagenesis in Salmonella typhimurium TA100 was reduced 38.5% while AFB1-induced mutagenesis was increased 36% by S9 from...
Topics
- Aflatoxin B1
- Aflatoxins
- Animals
- Benzo(a)pyrene
- Cricetinae
- DNA
- DNA Damage
- Glucose
- Glucuronates
- Glutathione
- Liver
- Male