Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epiregulin Recognition Mechanisms by Anti-epiregulin Antibody 9E5: STRUCTURAL, FUNCTIONAL, AND MOLECULAR DYNAMICS SIMULATION ANALYSES.

The Journal of biological chemistry - 29 Jan 2016

Kado Yuji, Mizohata Eiichi, Nagatoishi Satoru, Iijima Mariko, Shinoda Keiko, Miyafusa Takamitsu, Nakayama Taisuke, Yoshizumi Takuma, Sugiyama Akira, Kawamura Takeshi, Lee Young-Hun, Matsumura Hiroyoshi, Doi Hirofumi, Fujitani Hideaki, Kodama Tatsuhiko, Shibasaki Yoshikazu, Tsumoto Kouhei, Inoue Tsuyoshi

Abstract excerpt

Epiregulin (EPR) is a ligand of the epidermal growth factor (EGF) family that upon binding to its epidermal growth factor receptor (EGFR) stimulates proliferative signaling, especially in colon cancer cells. Here, we describe the three-dimensional structure of the EPR antibody (the 9E5(Fab) fragment) in the presence and absence of EPR. Among the six complementarity-determining regions (CDRs), CDR1-3 in the light...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Antibodies, Monoclonal, Humanized

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calorimetry

Share to Electron Spin Resonance Spectroscopy

Share to Immunoglobulin G

Share to Molecular Dynamics Simulation

Share to Mutagenesis, Site-Directed

Share to Surface Plasmon Resonance

Source

Open in PubMed Open full text

Identifiers

PMID: 26627827
DOI: 10.1074/jbc.M115.656009
PMCID: PMC4732215

Genes

EGFR
EGF
CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Epiregulin Recognition Mechanisms by Anti-epiregulin Antibody 9E5: STRUCTURAL, FUNCTIONAL, AND MOLECULAR DYNAMICS SIMULATION ANALYSES.PMID 26627827Read ↗

Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal CancerSemantic proximity Read ↗

Functional dissection of the epidermal growth factor receptor epitopes targeted by panitumumab and cetuximab.Semantic proximity Read ↗

Development of a human epidermal growth factor derivative with EGFR-blocking and depleted biological activities: A comparative in vitro study using EGFR-positive breast cancer cells.Semantic proximity Read ↗

Epitope Mapping of an Antihuman EGFR Monoclonal Antibody (EMab-134) Using the REMAP MethodSemantic proximity Read ↗

Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor familySemantic proximity Read ↗

Differential and synergistic effects of epidermal growth factor receptor antibodies on unliganded ErbB dimers and oligomers.Semantic proximity Read ↗

Structural basis for inhibition of the epidermal growth factor receptor by cetuximab.Semantic proximity Read ↗

Computational modeling and experimental validation of the EPI-X4/CXCR4 complex allows rational design of small peptide antagonistsSemantic proximity Read ↗

Inhibition of Cell Proliferation by an Anti-EGFR AptamerSemantic proximity Read ↗

Structural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8.Semantic proximity Read ↗

Structural and energetic hot-spots for the interaction between a ladder-like polycyclic ether and the anti-ciguatoxin antibody 10C9Fab.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.