Article
Peroxisome proliferator-activated receptor-gamma activation inhibits tumor metastasis by antagonizing Smad3-mediated epithelial-mesenchymal transition.
Molecular cancer therapeutics - 1 Dec 2010
Reka Ajaya Kumar, Kurapati Himabindu, Narala Venkata R, Bommer Guido, Chen Jun, Standiford Theodore J, Keshamouni Venkateshwar G
Abstract excerpt
Epithelial-mesenchymal transition (EMT) was shown to confer tumor cells with abilities essential for metastasis, including migratory phenotype, invasiveness, resistance to apoptosis, evading immune surveillance, and tumor stem cell traits. Therefore, inhibition of EMT can be an important therapeutic strategy to inhibit tumor metastasis. Here, we show that activation of peroxisome proliferator-activated receptor γ...
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