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Article

Concurrent genetic alterations in DNA polymerase proofreading and mismatch repair in human colorectal cancer.

European journal of human genetics : EJHG - 1 Mar 2011

Yoshida Rintaro, Miyashita Kaname, Inoue Mayuko, Shimamoto Akiyoshi, Yan Zhao, Egashira Akinori, Oki Eiji, Kakeji Yoshishiro, Oda Shinya, Maehara Yoshihiko

Abstract excerpt

Genomic sequences encoding the 3' exonuclease (proofreading) domains of both replicative DNA polymerases, pol delta and pol epsilon, were explored simultaneously in human colorectal carcinomas including six established cell lines. Three unequivocal sequence alterations, including one previously reported, were found, and all these were considered as dysfunctional mutations in light of the local amino-acid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21157497
DOI: 10.1038/ejhg.2010.216
PMCID: PMC3061989

Genes

MLH1
POLE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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