BAG1 is a protective factor for sporadic frontotemporal lobar degeneration but not for Alzheimer's disease.

doi:10.3233/JAD-2010-101416

Article

BAG1 is a protective factor for sporadic frontotemporal lobar degeneration but not for Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2011

Venturelli Eliana, Villa Chiara, Fenoglio Chiara, Clerici Francesca, Marcone Alessandra, Benussi Luisa, Ghidoni Roberta, Gallone Salvatore, Cortini Francesca, Serpente Maria, Cantoni Claudia, Fumagalli Giorgio, Ridolfi Elisa, Cappa Stefano, Binetti Giuliano, Franceschi Massimo, Rainero Innocenzo, Giordana Maria Teresa, Mariani Claudio, Bresolin Nereo, Scarpini Elio, Galimberti Daniela

Abstract excerpt

BCL2-associated athanogene 1 (BAG1) is an anti-apoptotic factor that interacts with tau and regulates its proteasomal degradation. A significant increase of the BAG-1M isoform was found in Alzheimer's disease (AD) brains, and the protein co-localized with tau and amyloid. We carried out an associ...

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