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Article

Effect of genetic variations in syntaxin-binding protein-5 and syntaxin-2 on von Willebrand factor concentration and cardiovascular risk.

Circulation. Cardiovascular genetics - 1 Dec 2010

van Loon Janine E, Leebeek Frank W G, Deckers Jaap W, Dippel Diederik W J, Poldermans Don, Strachan David P, Tang Weihong, O'Donnell Christopher J, Smith Nicholas L, de Maat Moniek P M

Abstract excerpt

BACKGROUND: Elevated von Willebrand factor (VWF) plasma levels are associated with an increased risk of cardiovascular disease. A meta-analysis of genomewide association studies on VWF identified novel candidate genes, that is, syntaxin-binding protein 5 (STXBP5) and syntaxin 2 (STX2), which are...

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Source

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Identifiers

PMID: 21156930
DOI: 10.1161/CIRCGENETICS.110.957407
PMCID: PMC3511837

Genes

VWF
STX2
STXBP5
ABO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21156930-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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