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The Double Game Played by Th17 Cells in Infection: Host Defense and Immunopathology

15 Dec 2022

Abstract excerpt

T-helper 17 (Th17) cells represent a subpopulation of CD4+ T lymphocytes that play an essential role in defense against pathogens. Th17 cells are distinguished from Th1 and Th2 cells by their ability to produce members of the interleukin-17 (IL-17) family, namely IL-17A and IL-17F. IL-17 in turn induces several target cells to synthesize and release cytokines, chemokines, and metalloproteinases, thereby...

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PMID: 36558881
DOI: 10.3390/pathogens11121547

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