Article
Inactivation of the Ecs ABC transporter of Staphylococcus aureus attenuates virulence by altering composition and function of bacterial wall.
PloS one - 2 Dec 2010
Jonsson Ing-Marie, Juuti Jarmo T, François Patrice, AlMajidi Rana, Pietiäinen Milla, Girard Myriam, Lindholm Catharina, Saller Manfred J, Driessen Arnold J M, Kuusela Pentti, Bokarewa Maria, Schrenzel Jacques, Kontinen Vesa P
Abstract excerpt
BACKGROUND: Ecs is an ATP-binding cassette (ABC) transporter present in aerobic and facultative anaerobic gram-positive Firmicutes. Inactivation of Bacillus subtilis Ecs causes pleiotropic changes in the bacterial phenotype including inhibition of intramembrane proteolysis. The molecule(s) transported by Ecs is (are) still unknown. METHODOLOGY/PRINCIPAL FINDINGS: In this study we mutated the ecsAB operon in two...
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