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Article

CMT2B-associated Rab7 mutants inhibit neurite outgrowth.

Acta neuropathologica - 1 Oct 2010

Cogli Laura, Progida Cinzia, Lecci Raffaella, Bramato Roberta, Krüttgen Alex, Bucci Cecilia

Abstract excerpt

Charco-Marie-Tooth type 2B (CMT2B) neuropathy is a rare autosomal-dominant axonal disorder characterized by distal weakness, muscle atrophy, and prominent sensory loss often complicated by foot ulcerations. CMT2B is associated with mutations of the Rab7 protein, a small GTPase controlling late endocytic traffic. Currently, it is still unknown how these mutations cause the neuropathy. Indeed, CMT2B selectively...

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Source

Identifiers

PMID: 20464402
DOI: 10.1007/s00401-010-0696-8

Genes

GAP43

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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