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Article

The mood stabilizer valproic acid improves defective neurite formation caused by Charcot-Marie-Tooth disease-associated mutant Rab7 through the JNK signaling pathway.

Journal of neuroscience research - 1 Nov 2010

Yamauchi Junji, Torii Tomohiro, Kusakawa Shinji, Sanbe Atsushi, Nakamura Kazuaki, Takashima Shou, Hamasaki Hajime, Kawaguchi Shogo, Miyamoto Yuki, Tanoue Akito

Abstract excerpt

Charcot-Marie-Tooth (CMT) disease is the most frequent peripheral neuropathy affecting the Schwann cells and neurons. CMT disease type 2 (CMT2) neuropathies are characterized by peripheral nerve aberrance. Four missense mutations of Rab7, a small GTPase of the Rab family involved in intracellular vesicular trafficking, are associated with the CMT2B phenotype. Despite a growing body of evidence concerning the gene...

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PMID: 20645406
DOI: 10.1002/jnr.22460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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