Article
Bacterial DNA motifs trigger ANCA production in ANCA-associated vasculitis in remission.
Rheumatology (Oxford, England) - 1 Apr 2011
Tadema Henko, Abdulahad Wayel H, Lepse Nikola, Stegeman Coen A, Kallenberg Cees G M, Heeringa Peter
Abstract excerpt
OBJECTIVES: CpG motifs, which are highly prevalent in bacterial DNA, have been shown to trigger the production of ANCA in vitro by B lymphocytes from patients with active ANCA-associated vasculitis (AAV). Staphylococcus aureus is associated with relapses in AAV, and CpG motifs from staphylococcal DNA may trigger ANCA production in AAV patients in remission. We investigated the presence of ANCA-producing B...
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