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Article

Disruption of Src function potentiates Chk1-inhibitor-induced apoptosis in human multiple myeloma cells in vitro and in vivo.

Blood - 10 Feb 2011

Dai Yun, Chen Shuang, Shah Rena, Pei Xin-Yan, Wang Li, Almenara Jorge A, Kramer Lora B, Dent Paul, Grant Steven

Abstract excerpt

Ras/MEK/ERK pathway activation represents an important compensatory response of human multiple myeloma (MM) cells to checkpoint kinase 1 (Chk1) inhibitors. To investigate the functional roles of Src in this event and potential therapeutic significance, interactions between Src and Chk1 inhibitors (eg, UCN-01 or Chk1i) were examined in vitro and in vivo. The dual Src/Abl inhibitors BMS354825 and SKI-606 blocked...

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Identifiers

PMID: 21148814
DOI: 10.1182/blood-2010-06-291146
PMCID: PMC3056642

Genes

UCN
ANG
SKI
TIMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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