Article

Hypoxia induces chemoresistance to proteasome inhibitors through orchestrating deSUMOylation and ubiquitination of SRC-3 in multiple myeloma

2022-05-31

Abstract excerpt

<title>Abstract</title> <p>The bone marrow microenvironment where multiple myeloma (MM) originated is hypoxic and an important stimulus for initiation of drug resistance to chemotherapies, but the underlying mechanisms and key regulators are still indistinct. In the current study, we found that hypoxia stimulus easily induced chemoresistance to proteasome inhibitors (PIs) but not to other chemicals, and the stero...

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Literature Corpus work: a1071295-5550-5428-b05a-8aeaa4c9a6a3
DOI: 10.21203/rs.3.rs-1658047/v1

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