Article
Viral sequence evolution in Chinese genotype 1b chronic hepatitis C patients experiencing unsuccessful interferon treatment.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Mar 2011
Xiang Xiaogang, Lu Jie, Dong Zhixia, Zhou Huijuan, Tao Wanyin, Guo Qing, Zhou Xiaqiu, Bao Shisan, Xie Qing, Zhong Jin
Abstract excerpt
The efficiencies of IFN-α based therapy in chronic genotype 1b HCV patients are still unsatisfied to date. The mechanisms underlining treatment failure remain unclear and controversial. To investigate HCV sequence evolution in unsuccessfully treated genotype 1b patients before, during and after the therapy, full-length open-reading-frame of HCV genomes at week 0, week 48 and year 5 in one breakthrough and one...
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