Article
Drosophila Ube3a regulates monoamine synthesis by increasing GTP cyclohydrolase I activity via a non-ubiquitin ligase mechanism.
Neurobiology of disease - 1 Mar 2011
Ferdousy Faiza, Bodeen William, Summers Kyle, Doherty Olugbenga, Wright O'Neil, Elsisi Nahed, Hilliard George, O'Donnell Janis M, Reiter Lawrence T
Abstract excerpt
The underlying defects in Angelman syndrome (AS) and autism spectrum disorder (ASD) may be in part due to basic defects in synaptic plasticity and function. In some individuals serotonin reuptake inhibitors, which decrease pre-synaptic re-uptake of serotonin, can ameliorate symptoms, as can resperidone, which blocks both dopamine and serotonin receptors. Loss of maternal UBE3A expression causes AS, while maternal...
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