Article
Finasteride metabolism and pharmacogenetics: new approaches to personalized prevention of prostate cancer.
Future oncology (London, England) - 1 Dec 2010
Hulin-Curtis Sarah L, Petit Dominique, Figg W Douglas, Hsing Ann W, Reichardt Juergen K V
Abstract excerpt
Incidences of prostate cancer in most countries are increasing owing to better detection methods; however, prevention with the use of finasteride, a very effective steroid 5α-reductase type II inhibitor, has been met with mixed success. A wide interindividual variation in response exists and is thought to be due to heritable factors. This article summarizes the literature that attempts to elucidate the molecular...
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