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Article

Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase.

1 Jan 1992

Abstract excerpt

The enzyme steroid 5 alpha-reductase catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone, and impairment of this reaction causes a form of male pseudohermaphroditism in which genetic males differentiate predominantly as phenotypic females. We previously isolated cDNA clones that encode a human steroid 5 alpha-reductase enzyme. Here, we report molecular and genetic studies...

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PMID: 1345916
DOI: 10.1172/jci115574

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