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Article

Sitimagene Ceradenovec: A Gene-Based Drug for the Treatment of Operable High-Grade Glioma

9 Dec 2010

Abstract excerpt

The field of gene therapy for malignant glioma has made important advances since the first gene transfer studies were performed 20 years ago. Multiple Phase I/II trials and two Phase III trials have been performed and have demonstrated the feasibility and safety of intratumoral vector delivery in the brain. Sitimagene ceradenovec is an adenoviral vector encoding the herpes simplex thymidine kinase gene, developed...

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PMID: 21142657
DOI: 10.2217/fon.10.134

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