Article
NFKB1 insertion/deletion promoter polymorphism increases the risk of advanced ovarian cancer in a Chinese population.
DNA and cell biology - 1 Apr 2011
Fan Yaxin, Yu Weijian, Ye Ping, Wang Huali, Wang Zhongmin, Meng Qingli, Duan Ying, Liang Xiaohua, An Wanxin
Abstract excerpt
Ovarian cancer is the leading cause of death among all gynecological cancers. This is mainly attributed to its frequent presentation at an advanced stage (International Federation of Gynecology and Obstetrics stage III-IV). Nuclear factor-kappaB (NF-κB) is critically involved in the carcinogenesis and development of ovarian cancer. A functional insertion/deletion polymorphism (-94 ins/del ATTG) in the promoter...
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