Inducible production of macrophage colony-stimulating factor (CSF-1) by malignant and normal human T cells.

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Article

Inducible production of macrophage colony-stimulating factor (CSF-1) by malignant and normal human T cells.

Leukemia - 1 Jun 1990

Praloran V, Gascan H, Papin S, Chevalier S, Trossaërt M, Boursier M C

Abstract excerpt

The CEM-ON malignant T cell line and long-term cultured normal T cells can be induced to release CSF-1 in their culture supernatants. Chemical inducers (PMA + A23187) and, more interestingly, cytokines (tumor necrosis factor alpha (TNF alpha) and interleukin-1 alpha (IL-1 alpha)), as well as physiological (antigen + IL-2) or specific (anti-CD3 + IL-2 or PMA) stimuli, lead to rapid transient colony-stimulating...

Topics

Antigens, Differentiation, T-Lymphocyte
Blotting, Northern
Calcimycin
Cells, Cultured
Colony-Forming Units Assay
Colony-Stimulating Factors
Humans
Interleukin-1
Leukemia, T-Cell
Macrophage Colony-Stimulating Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Monocytes

Phenotype

RNA, Messenger

T-Lymphocytes

Tetradecanoylphorbol Acetate

Tumor Cells, Cultured

Tumor Necrosis Factor-alpha

Source

Open in PubMed

Identifiers

PMID: 2113600

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2113600-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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