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Article

Reversing the Hemoglobin Switch

1 Dec 2010

Abstract excerpt

Natural observations can often provide important clues for how therapies can be developed to ameliorate disease. Disorders of β-hemoglobin, including sickle cell disease and β-thalassemia, are good examples of this maxim, since a variety of clinical observations have shown that increased levels of fetal hemoglobin can ameliorate the severity of these diseases. This observation has led to the decades-long hunt for...

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PMID: 21121839
DOI: 10.1056/nejmcibr1010767

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