HMG CoA reductase inhibitors as lipid-lowering agents: five years experience with lovastatin and an appraisal of simvastatin and pravastatin.

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Article

HMG CoA reductase inhibitors as lipid-lowering agents: five years experience with lovastatin and an appraisal of simvastatin and pravastatin.

The Quarterly journal of medicine - 1 Feb 1990

Maher V M, Thompson G R

Abstract excerpt

The HMG CoA reductase inhibitors are the most effective drugs for treating hypercholesterolaemia currently available. They inhibit cholesterol synthesis and thus stimulate receptor-mediated uptake and degradation of low-density lipoprotein cholesterol by the liver. In 30 patients with severe hypercholesterolaemia administration of lovastatin alone or in combination with other lipid-lowering manoeuvres maintained...

Topics

Adult
Aged
Anticholesteremic Agents
Cholestyramine Resin
Clinical Trials as Topic
Dose-Response Relationship, Drug
Drug Therapy, Combination
Female
Heptanoic Acids
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hypercholesterolemia

Lovastatin

Male

Middle Aged

Naphthalenes

Phenotype

Pravastatin

Source

Open in PubMed

Identifiers

PMID: 2111917

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2111917-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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