Article
The NPC motif of aquaporin-11, unlike the NPA motif of known aquaporins, is essential for full expression of molecular function.
The Journal of biological chemistry - 4 Feb 2011
Ikeda Masahiro, Andoo Ayaka, Shimono Mariko, Takamatsu Natsuko, Taki Asaka, Muta Kanako, Matsushita Wataru, Uechi Tamayo, Matsuzaki Toshiyuki, Kenmochi Naoya, Takata Kuniaki, Sasaki Sei, Ito Katsuaki, Ishibashi Kenichi
Abstract excerpt
The recently identified molecule aquaporin-11 (AQP11) has a unique amino acid sequence pattern that includes an Asn-Pro-Cys (NPC) motif, corresponding to the N-terminal Asn-Pro-Ala (NPA) signature motif of conventional AQPs. In this study, we examined the effect of the mutation of the NPC motif on the subcellular localization, oligomerization, and water permeability of AQP11 in transfected mammalian cells....
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