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Article

Ongoing purifying selection on intergenic spacers in group A streptococcus.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Mar 2011

Luo Haiwei, Tang Jijun, Friedman Robert, Hughes Austin L

Abstract excerpt

Bacterial intergenic spacers are non-coding genomic regions enriched with cis-regulatory elements for gene expression. A population genetics approach was used to investigate the evolutionary force shaping the genetic diversity of intergenic spacers among 13 genomes of group A streptococcus (GAS). Analysis of 590 genes and their linked 5' intergenic spacers showed reduced nucleotide diversity in spacers compared...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Gene Expression

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Share to Regulatory Elements, Transcriptional

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Source

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Identifiers

PMID: 21115137
DOI: 10.1016/j.meegid.2010.11.005
PMCID: PMC3411356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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