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Article

GABAA receptor open-state conformation determines non-competitive antagonist binding.

Toxicology and applied pharmacology - 1 Feb 2011

Chen Ligong, Xue Ling, Giacomini Kathleen M, Casida John E

Abstract excerpt

The γ-aminobutyric acid (GABA) type A receptor (GABA(A)R) is one of the most important targets for insecticide action. The human recombinant β3 homomer is the best available model for this binding site and 4-n-[(3)H]propyl-4'-ethynylbicycloorthobenzoate ([(3)H]EBOB) is the preferred non-competiti...

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Share to Binding, Competitive
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Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21111751
DOI: 10.1016/j.taap.2010.11.010
PMCID: PMC3056339

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21111751-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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