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Article

Determinants of visual pigment absorbance: role of charged amino acids in the putative transmembrane segments.

Biochemistry - 30 Jan 1990

Nathans J

Abstract excerpt

I have investigated the effect on bovine rhodopsin's absorbance spectrum of charged amino acid changes in the putative membrane-spanning regions. A total of 14 site-directed mutants were constructed at 6 amino acid positions: 83, 86, 122, 134, 135, and 211. Two of these positions are occupied by charged amino acids that are conserved in all four human visual pigments (positions 134 and 135). In the four variable...

Topics

Amino Acid Sequence
Animals
Arginine
Aspartic Acid
Cattle
Gene Expression
Glutamates
Histidine
Lysine
Membrane Proteins
Molecular Sequence Data
Molecular Structure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Retinal Pigments

Retinaldehyde

Rhodopsin

Spectrophotometry

Source

Identifiers

PMID: 2111169
DOI: 10.1021/bi00456a013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2111169-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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