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Article

Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics.

Clinical pharmacology and therapeutics - 1 Jan 2011

Ji Y, Hebbring S, Zhu H, Jenkins G D, Biernacka J, Snyder K, Drews M, Fiehn O, Zeng Z, Schaid D, Mrazek D A, Kaddurah-Daouk R, Weinshilboum R M

Abstract excerpt

Major depressive disorder (MDD) is a common psychiatric disease. Selective serotonin reuptake inhibitors (SSRIs) are an important class of drugs used in the treatment of MDD. However, many patients do not respond adequately to SSRI therapy. We used a pharmacometabolomics-informed pharmacogenomic research strategy to identify citalopram/escitalopram treatment outcome biomarkers. Metabolomic assay of plasma samples...

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Identifiers

PMID: 21107318
DOI: 10.1038/clpt.2010.250
PMCID: PMC3034442

Genes

GLDC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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