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Article

Mitochondrial haplogroups A and M7a confer a genetic risk for coronary atherosclerosis in the Japanese elderly: an autopsy study of 1,536 patients.

Journal of atherosclerosis and thrombosis - 1 Jan 2011

Sawabe Motoji, Tanaka Masashi, Chida Kouji, Arai Tomio, Nishigaki Yutaka, Fuku Noriyuki, Mieno Makiko Naka, Kuchiba Aya, Tanaka Noriko

Abstract excerpt

AIM: We previously reported significant associations between mitochondrial single nucleotide polymorphisms (mtSNPs) and myocardial infarction, atherothrombotic cerebral infarction, metabolic syndrome and type 2 diabetes. Here, we assessed the hypothesis that mtSNPs may confer a risk for atherosclerosis, the most important intermediate phenotype of ischemic cardiovascular events. METHODS: The subjects were 1,536...

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Identifiers

PMID: 21099167
DOI: 10.5551/jat.6742

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