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Integration of host-related signatures with cancer cell-derived predictors for the optimal management of anticancer chemotherapy.

Cancer research - 1 Dec 2010

Zitvogel Laurence, Kepp Oliver, Aymeric Laetitia, Ma Yuting, Locher Clara, Delahaye Nicolas F, André Fabrice, Kroemer Guido

Abstract excerpt

Current cancer management aims to integrate molecular signatures into the design of personalized therapies. Recent advances in "omics" done on tumor specimens have led to the identification of factors that either recognize cancers of dismal prognosis or pinpoint "druggable" signaling pathways, which can be interrupted by targeted therapies. However, accumulating evidence underscores the biological and clinical...

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PMID: 21098713
DOI: 10.1158/0008-5472.CAN-10-1003

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