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Article

A flexible multiplex bead-based assay for detecting germline CDKN2A and CDK4 variants in melanoma-prone kindreds.

The Journal of investigative dermatology - 1 Feb 2011

Lang Julie M, Shennan Michael, Njauw Jenny C-N, Luo Su, Bishop Julia N, Harland Mark, Hayward Nicholas K, Tucker Margaret A, Goldstein Alisa M, Landi Maria T, Puig Susana, Gruis Nelleke A, Bergman Wilma, Bianchi-Scarra Giovanna, Ghiorzo Paola, Hogg David, Tsao Hensin

Abstract excerpt

The presence of recurrent high-risk mutations in cyclin-dependent kinase inhibitor 2A/cyclin-dependent kinase 4 (CDKN2A/CDK4) among melanoma-prone families suggests that a high-throughput, multiplex assay could serve as an effective initial screening tool. To this end, we have developed a multiplex bead-based assay for high-throughput CDKN2A/CDK4 genotyping in the context of familial melanoma. Genomic DNA from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 21085193
DOI: 10.1038/jid.2010.331
PMCID: PMC3045700

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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