Acute intravenous synaptamine complex variant KB220™ "normalizes" neurological dysregulation in patients during protracted abstinence from alcohol and opiates as observed using quantitative electroencephalographic and genetic analysis for reward polymorphisms: part 1, pilot study with 2 case reports.

doi:10.3810/pgm.2010.11.2236

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Article

Acute intravenous synaptamine complex variant KB220™ "normalizes" neurological dysregulation in patients during protracted abstinence from alcohol and opiates as observed using quantitative electroencephalographic and genetic analysis for reward polymorphisms: part 1, pilot study with 2 case reports.

Postgraduate medicine - 1 Nov 2010

Miller David K, Bowirrat Abdalla, Manka Matthew, Miller Merlene, Stokes Stanley, Manka Debra, Allen Cameron, Gant Charles, Downs B William, Smolen Andrew, Stevens Emily, Yeldandi Swetha, Blum Kenneth

Abstract excerpt

It is well established that in both food- and drug-addicted individuals, there is dopamine resistance due to an association with the DRD2 gene A1 allele. Evidence is emerging whereby the potential of utilizing a natural, nonaddicting, safe, putative D2 agonist may find its place in recovery from reward deficiency syndrome (RDS) in patients addicted to psychoactive chemicals. Utilizing quantitative...

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Identifiers

PMID: 21084795
DOI: 10.3810/pgm.2010.11.2236

Genes

DRD2
COMT
DRD4
MAOA

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