Article
Hepatic lipase: site-directed mutagenesis of a serine residue important for catalytic activity.
The Journal of biological chemistry - 15 Apr 1990
Davis R C, Stahnke G, Wong H, Doolittle M H, Ameis D, Will H, Schotz M C
Abstract excerpt
Hepatic lipase (HL) is a member of the lipoprotein lipase/pancreatic lipase gene family and is believed to function in processing of intermediate and high density lipoproteins. As a lipase, HL is presumed to have a lipid interfacial binding domain, distinct from the esterase catalytic site, orienting the enzyme at aqueous-lipid interfaces and resulting in activation of esterase activity. However, the structural...
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