Article
Intracellular and cell-to-cell spread of Listeria monocytogenes involves interaction with F-actin in the enterocytelike cell line Caco-2.
Infection and immunity - 1 Apr 1990
Mounier J, Ryter A, Coquis-Rondon M, Sansonetti P J
Abstract excerpt
Listeria monocytogenes penetrates and multiplies within professional phagocytes and other cells such as the Caco-2 human enterocytelike cell line. Listeriolysin O, a membrane-damaging cytotoxin accounts for intracellular multiplication through lysis of the membrane-bound phagocytic vacuole. This work demonstrates that once released within the cytosol, L. monocytogenes acquires the capacity to spread...
Topics
- Actin Cytoskeleton
- Actins
- Colonic Neoplasms
- Gold
- Humans
- Listeria monocytogenes
- Microscopy, Electron
- Microtubules
- Movement
- Mutation
- Phagosomes
- Tumor Cells, Cultured