Article
Lmo0171, a novel internalin-like protein, determines cell morphology of Listeria monocytogenes and its ability to invade human cell lines.
Current microbiology - 1 Feb 2015
Stachowiak Radosław, Jagielski Tomasz, Roeske Katarzyna, Osińska Olga, Gunerka Paweł, Wiśniewski Jarosław, Bielecki Jacek
Abstract excerpt
Internalins comprise a class of Listeria monocytogenes proteins responsible for activation of signalling pathways leading to phagocytic uptake of the bacterium by the host cell. In this paper, a possible role of Lmo0171-a new member of the internalin family was investigated. Disruption of the lmo0171 gene resulted in important cell morphology alterations along with a decrease in the ability to invade three...
Topics
- Bacterial Proteins
- Cell Line
- Gene Order
- HeLa Cells
- Humans
- Listeria monocytogenes
- Mutagenesis
- Mutation
- Virulence