Article
Impact of glutamine transporters on pneumococcal fitness under infection-related conditions.
Infection and immunity - 1 Jan 2011
Härtel Tobias, Klein Matthias, Koedel Uwe, Rohde Manfred, Petruschka Lothar, Hammerschmidt Sven
Abstract excerpt
The genomic analysis of Streptococcus pneumoniae predicted six putative glutamine uptake systems, which are expressed under in vitro conditions, as shown here by reverse transcription-PCR. Four of these operons consist of glnHPQ, while two lack glnH, which encodes a soluble glutamine-binding protein. Here, we studied the impact of two of these glutamine ATP-binding cassette transporters on S. pneumoniae D39...
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