Article
MicroRNA profiling reveals aberrant microRNA expression in adult ETP-ALL and functional studies implicate a role for miR-222 in acute leukemia.
Leukemia research - 1 Jun 2013
Coskun Ebru, Neumann Martin, Schlee Cornelia, Liebertz Frauke, Heesch Sandra, Goekbuget Nicola, Hoelzer Dieter, Baldus Claudia D
Abstract excerpt
Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) has been identified as high-risk subgroup in acute T-cell lymphoblastic leukemia (T-ALL). To investigate the immature and myeloid nature of ETP-ALL we examined global microRNA (miRNA) expression in adult ETP-ALL. miRNA profiling of ETP-ALL (n=8), non-ETP T-ALL (n=6), and healthy controls was performed and results were validated in independent cohorts...
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