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Article

miR-221/222 Target the DNA Methyltransferase MGMT in Glioma Cells

19 Sept 2013

Abstract excerpt

Glioblastoma multiforme (GBM) is one of the most deadly types of cancer. To date, the best clinical approach for treatment is based on administration of temozolomide (TMZ) in combination with radiotherapy. Much evidence suggests that the intracellular level of the alkylating enzyme O(6)-methylguanine-DNA methyltransferase (MGMT) impacts response to TMZ in GBM patients. MGMT expression is regulated by the...

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PMID: 24147153
DOI: 10.1371/journal.pone.0074466

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