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Article

β-globin genes: mutation hot-spots in the global thalassemia belt.

Hemoglobin - 1 Jan 2015

Kumar Rakesh, Sagar Chandan, Sharma Dharmesh, Kishor Purnima

Abstract excerpt

The concurrence of malaria and hemoglobinopathies, observed in malaria endemic regions, reflects the phenomenon of natural selection. Since the life cycle of the malaria parasite has an erythrocytic stage, abnormalities in the red blood cells (RBCs) hinder the parasite's survival in the human host. Hemoglobin (Hb) variants affect the life span of RBCs and thus lower the chance of infection by the parasite. While...

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Identifiers

PMID: 25523871
DOI: 10.3109/03630269.2014.985831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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