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Article

Associations of tryptophan hydroxylase gene polymorphisms with irritable bowel syndrome.

Neurogastroenterology and motility - 1 Mar 2011

Jun S, Kohen R, Cain K C, Jarrett M E, Heitkemper M M

Abstract excerpt

BACKGROUND: Alterations in serotonin (5-HT) are suspected in the pathophysiology of irritable bowel syndrome (IBS). Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin and has two isoforms: TPH1 and TPH2. Genetic variants in both genes have been studied in various disorders related to serotonin dysregulation. The aim of this study was to examine whether TPH gene variants were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 21073637
DOI: 10.1111/j.1365-2982.2010.01623.x
PMCID: PMC3057463

Genes

TPH1
TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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