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Article

Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes.

The American journal of gastroenterology - 1 Nov 2013

Grasberger Helmut, Chang Lin, Shih Wendy, Presson Angela P, Sayuk Gregory S, Newberry Rodney D, Karagiannides Iordanis, Pothoulakis Charalabos, Mayer Emeran, Merchant Juanita L

Abstract excerpt

OBJECTIVES: Alterations in 5-hydroxytryptamine (5-HT) signaling have been implicated as a factor contributing to the altered bowel habit of irritable bowel syndrome (IBS) patients. Tryptophan hydroxylase 1 (TPH1) is the rate-limiting enzyme in enterochromaffin cell 5-HT biosynthesis. We hypothesized that genetic variants affecting TPH1 gene expression might alter intestinal 5-HT bioavailability and subsequently...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Early Growth Response Protein 1

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Share to Promoter Regions, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 24060757
DOI: 10.1038/ajg.2013.304
PMCID: PMC4067697

Genes

TPH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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