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Article

PP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins.

PloS one - 1 Nov 2010

Godet Angélique N, Guergnon Julien, Croset Amélie, Cayla Xavier, Falanga Pierre Barthélemy, Colle Jean-Hervé, Garcia Alphonse

Abstract excerpt

BACKGROUND: The hallmark of HIV-1 pathogenesis is the progressive CD4(+) T cell depletion and high propensity of CD4(+) T cells to apoptosis. HIV-1 viral protein R (Vpr) is a major pro-apoptotic gene product. A first Vpr-mediated apoptotic mechanism that requires a physical interaction of HIV-1 V...

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Source

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Identifiers

PMID: 21072166
DOI: 10.1371/journal.pone.0013760
PMCID: PMC2967473

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21072166-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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