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Article

The HIV‐1 Vpr displays strong anti‐apoptotic activity

31 Jul 1998

Abstract excerpt

Mutations in the human immunodeficiency virus type 1 (HIV-1) vpr gene only slightly reduce the replication rate of the virus. To study the role of HIV-1 Vpr in biological effects on cells, HEp-2 cells, which express HIV-1 Vpr constitutively but at a low level, were established. While control HEp-2 cells underwent apoptosis when incubated with sorbitol, the morphological and biochemical apoptotic changes were...

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PMID: 9710242
DOI: 10.1016/s0014-5793(98)00824-2

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