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The Receptor-Binding Domain of Influenza Virus Hemagglutinin Produced in <i>Escherichia coli</i> Folds into Its Native, Immunogenic Structure

11 Nov 2010

Abstract excerpt

The hemagglutinin (HA) surface glycoprotein promotes influenza virus entry and is the key protective antigen in natural immunity and vaccines. The HA protein is a trimeric envelope glycoprotein consisting of a globular receptor-binding domain (HA-RBD) that is inserted into a membrane fusion-mediating stalk domain. Similar to other class I viral fusion proteins, the fusogenic stalk domain spontaneously refolds...

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PMID: 21068239
DOI: 10.1128/jvi.01412-10

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