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Article

Rab25 as a tumour suppressor in colon carcinogenesis

9 Nov 2010

Abstract excerpt

Recent investigations have increasingly focussed attention on the roles of intracellular vesicle trafficking in the regulation of epithelial polarity and transformation. Rab25, an epithelial-specific member of the Rab family of small GTPases, has been associated with several epithelial cancers. Whereas Rab25 overexpression is associated with ovarian cancer aggressive behaviour, Rab25 expression is decreased in...

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PMID: 21063400
DOI: 10.1038/sj.bjc.6605983

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