Article
SCN5A mutation is associated with early and frequent recurrence of ventricular fibrillation in patients with Brugada syndrome.
Circulation journal : official journal of the Japanese Circulation Society - 1 Nov 2010
Nishii Nobuhiro, Ogawa Masahiro, Morita Hiroshi, Nakamura Kazufumi, Banba Kimikazu, Miura Daiji, Kumagai Naoko, Matsunaga Akira, Kawamura Hiroshi, Urakawa Shigemi, Miyaji Kohei, Nagai Masahiro, Satoh Katsumasa, Nakagawa Koji, Tanaka Masamichi, Hiramatsu Shigeki, Tada Takeshi, Murakami Masato, Nagase Satoshi, Kohno Kunihisa, Kusano Kengo Fukushima, Saku Keijiro, Ohe Tohru, Ito Hiroshi
Abstract excerpt
BACKGROUND: Mutations in SCN5A are reportedly linked to Brugada syndrome (BS), but recent observations suggest that they are not necessarily associated with ventricular fibrillation (VF) in BS patients. Therefore, the clinical importance of SCN5A mutations in BS patients was examined in the present study. METHODS AND RESULTS: The 108 BS patients were examined for SCN5A mutations and various parameters were...
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